Fig. 7 | Scientific Reports

Fig. 7

From: Cystathionine-γ-lyase contributes to tamoxifen resistance, and the compound I194496 alleviates this effect by inhibiting the PPARγ/ACSL1/STAT3 signalling pathway in oestrogen receptor-positive breast cancer

Fig. 7

Application of I194496 increased the inhibitory effect of TAM on the growth, proliferation, migration effect of breast cancer cells. (A) The chemical structure of the compound I194496. (B–E) Effect of applying I194496 on the growth of T47D/CSE and MCF7/TAM cells was detected by MTS assay. All data are expressed as mean ± standard deviation (n = 3). *P < 0.05 versus 0 μM I194496 group. (F,G,I) Effect of applying I194496 in combination with TAM on the growth and proliferation of T47D/CSE and MCF7/TAM cells was detected by EdU assays. Scale bars, 100 µm. All data are expressed as mean ± standard deviation (n = 3). *P < 0.05, **P < 0.01 versus 4-OH TAM group. (H,J) Effect of applying I194496 in combination with TAM on the migration of T47D/CSE cells was detected by wound healing assay. Representative images were taken. Scale bars, 500 µm.

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