Table 1 Aberrant genes in ATC immune microenvironment.

From: New insights into the mechanisms of the extracellular matrix and its therapeutic potential in anaplastic thyroid carcinoma

Gene name

Differential expression in ATC

Biological processes/cellular functions

References

METTL3

↓

increased the abundance of the immunosuppressive Tregs and terminally exhausted T cells

19

SIGLEC15

↑

interacted with T cells by immunosuppressive signals such as CXCL12-CXCR4

20

CD1d

↑

a receptor for NKT cells

21

PPARGC1A

↑

inhibited immune cell infiltrations

22

TLR4

↑

shaped the immunosuppressive microenvironment

23,24

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