Fig. 7 | Scientific Reports

Fig. 7

From: Helicobacter pylori CagA mediated mitophagy to attenuate the NLRP3 inflammasome activation and enhance the survival of infected cells

Fig. 7

Inhibition of Mitophagy can increase apoptosis, and decrease the cell viability of H. pylori infected cells. AGS and GES-1 cells were pretreated with mitophagy inhibitor (BafA1, 10 μM) for 24 h, respectively, and then infected with GZ7/cagA and GZ7/Δ cagA at an MOI of 60. (A) The apoptosis rate of H. pylori-infected cells were detected by flow cytometry after H. pylori infection 48 h. (B) The cell viability of H. pylori-infected cells were detected by CCK8 assay after H. pylori infection 6 h, 24 h and 48 h. The figure presents the average of three independent experiments. Data are presented as the means ± SD. Error bars represent the standard deviation. control, the uninfected cells; GZ7/ΔcagA, the GZ7/ΔcagA strains infected cells; GZ7/cagA, the GZ7/cagA strains infected cells; *p < 0.05, **p < 0.01; GZ7/cagA vs control, GZ7/cagA vs BafA1 + GZ7/cagA, BafA1 + GZ7/cagA vs BafA1 + GZ7/ΔcagA.

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