Fig. 3 | Scientific Reports

Fig. 3

From: Heterogeneous expression of the atypical chemokine receptor ACKR3 in glioblastoma patient-derived tissue samples and cell cultures

Fig. 3

Characterization of ACKR3-positive cells in glioblastoma tissue. (A–B) Immunofluorescent staining of ACKR3 (green) and cell type specific markers, including SOX2, GFAP, Iba1, EGFR, PDGFRb and CXCR4 (red). DAPI (blue) was used to counterstain nuclei. Scale bar = 10 μm. (C) ACKR3 expression in various cell types within patient glioma samples. Single cell RNAseq data from Neftel 2019 dataset8 show ACKR3 expression in different cell types. The “% expressing” value indicates the proportion of cells in the signature that are positive for a given transcript, and the “scaled mean expression” is relative to each gene expression level (logTPM) across all cells within the signature (using Single Cell Portal online platform).

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