Fig. 1 | Scientific Reports

Fig. 1

From: Exploring the progression of drug dependence in a methamphetamine self-administration rat model through targeted and non-targeted metabolomics analyses

Fig. 1

Summary of animal behavior experiments. (A) Timeline, experimental sessions, and animal groups for behavioral assessment. Gray circle represents the day of blood collection. (B) Numbers of infusions and lever presses during the self-administration period (1–16 days) of Groups S and M. (C) Numbers of infusions and lever presses during self-administration (1–16 days) and extinction period (17–30 days) of Groups SS and MS. (D) Numbers of infusions and lever presses during self-administration (1–16 days), extinction (17–30 days), and reinstatement period (31 day) of Groups MSS and MSM. Statistical analyses were performed using the two-way ANOVA test, followed by Bonferroni’s multiple comparison post hoc test. The data are presented as mean ± standard error of the mean (SEM). *p < 0.05, **p < 0.01, ***p < 0.001 for daily comparison between groups; ##p < 0.01, ###p < 0.001 for total comparison between groups. NS, not significant; SAL, saline; MA, methamphetamine; Ac, active lever; InA, inactive lever.

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