Table 1 Comparison between patients with HBV-ACLF and those with CHB at baseline.

Variable	CHB	ACLF	p-value^†
Variable	(n = 33)	(n = 33)	p-value^†
Sex
Male	28	29	ns
Female	5	4	ns
ALT (U/L)	23 [17, 45.5]	92 [55.50, 264.50]	0.000
AST (U/L)	22.5 [18.00, 37.5]	139 [71.50, 238.00]	0.000
BA	10 [4, 32]	217 [152.5, 260.5]	0.000
TBil (µmol/L)	15.45 [10.50, 19.40]	306 [240.4, 418.25]	0.000
DBil (µmol/L)	5.15 [3.60, 7.10]	230 [178.45, 316.2]	0.000
AFP (ng/mL)	2.42 [1.44, 5.85]	36.26 [12.51, 105.7]	0.000
WBC (×10⁹/L)	4.98 [4.22, 5.99]	7.97 [5.49, 11.59]	0.000
RBC (×10¹²/L)	4.61 [4.12, 4.98]	3.28 [2.98, 3.79]	0.000
Cr	83 [78, 90]	86 [76, 101]	ns
LA	3 [2.73, 4.55]	1.84 [1.29, 2.9]	0.006
CRP	1.2 [0.5, 1.9]	9.6 [6.45, 19.35]	0.000
PCT	0.033 [0.021, 0.114]	0.66 [0.33, 0.95]	0.000
INR	1.04 [0.99, 1.07]	1.9 [1.72, 2.15]	0.000
SF (ng/mL)	222.3 [89.87, 531.32]	1354 [496.75, 1735]	0.001
PTA	93.80 [83.05, 108.90]	34.70 [30.10, 40.95]	0.000
			t-test
Age	52 [40.75, 58.00]	49 (40.00, 57.0)	ns
MELD	5.57 [3.63, 7.49]	18.22 (15.5, 19.98)	0.000
PLT (×10⁹/L)	157 [101, 179.5]	73 (49.1, 19.5)	0.000

^†Analysis was performed using the Mann–Whitney U test or t-test, and statistical significance was set at p values < 0.05.
ALT alanine aminotransferase, AST aspartate aminotransferase, PTA prothrombin activity, BA bile acids, TBIL total bilirubin, DBil direct bilirubin, AFP alpha-fetoprotein, WBC white blood cell, RBC red blood cell, Cr creatinine, LA lactic acid, PLT blood platelet, SF serum ferritin, ns not significant, CHB chronic hepatitis B, ACLF acute-on-chronic liver failure.

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