Table 2 Variation in clinical and analytical parameters at baseline, 1 h, 2 h, 6 h, 12 h and 24 h after each HSA bolus (n = 64). Analytical parameters were only asessed every 24 hours.

SBP (mmHg)

76 (15)

82 (14) *

78 (16) *

84 (18) *

84 (18) *

85 (18) *

MBP (mmHg)

54 (9)

57 (10) *

56 (9) *

58 (10) *

60 (8) *

61 (10) *

DBP (mmHg)

42 (9)

44 (10)

43 (9)

46 (11) *

46 (8) *

48 (10) *

CVP (mmHg)

14 (5)

14 (5)

14 (5)

14 (5)

13 (5)

13 (4)

HR (bpm)

136 (24)

135 (25)

135 (24)

135 (25)

137 (22)

137 (21)

VIS

48 (32)

50 (32)

51 (36)

50 (34)

44 (30)

39 (29) *

UO (ml/kg/h)

2.7 (3.7)

2.7 (3.4)

2.5 (3)

3.7 (4.5)

3 (3)

2.9 (2.8)

Sodium (mEq/L)

140 (5)

143 (5)

142 (6)

142 (5)

142 (5)

140 (6)

Chloride (mEq/L)

105 (7)

109 (7) *

109 (7)

107 (6)

107 (7)

105 (7)

pH

7.35 (0.09)

7.32 (0.08)

7.33 (0.09)

7.35 (0.09)

7.40 (0.07) *

7.41 (0.06) *

HCO₃(mmol/L)

26.2 (5.2)

24 (4.3)

25.4 (5.4)

26.8 (5.1)

27.7 (4.8)

28.3 (4.2) *

Lactate (mmol/L)

1.9 (1.9)

2.3 (2.3)

1.9 (1.6)

2 (2)

1.9 (1.9)

1.4 (0.8) *

Albumin (g/dl)

3.3 (0.5)

-

-

-

-

3.7 (0.5) *

Creatinine (mg/dl)

0.53 (0.3)

-

-

-

-

0.52 (0.3)

Urea (g/dl)

48 (30)

-

-

-

-

47 (28)

INR

2.5 (6)

-

-

-

-

2.7 (7.7)

Fibrinogen (mg/dl)

355 (158)

-

-

-

-

405 (167) *

aPTT (seg)

49.4 (27)

-

-

-

-

50 (29)

Platelets (10³/mcL)

152 (82)

-

-

-

-

141 (84)

Hemoglobin (g/dl)

11.7 (3.4)

-

-

-

-

11.5 (3.2)