Table 1 Cytotoxic activities of compounds 1 and 2 on HCT-116 and HepG2 cancer cell lines.
Cell line name | Conc. (µg/ml) | 1 | 2 | ||||
---|---|---|---|---|---|---|---|
Viability % | IC50 (µg/mL) | SI | Viability % | IC50 (µg/mL) | SI | ||
Wi38 | 100 | 58.93 ± 0.21 | 112.5 ± 3.42 | -- | 49 ± 1.0 | 97.2 ± 2.14 | -- |
50 | 71.9 ± 0.95 | 64.33 ± 0.33 | |||||
25 | 80.83 ± 0.72 | 76.86 ± 0.69 | |||||
12.5 | 95.23 ± 0.67 | 90.33 ± 0.88 | |||||
6.25 | 99.66 ± 0.33 | 95 ± 1.0 | |||||
0 | 100 ± 0.0 | 100 ± 0.0 | |||||
HCT-116 | 100 | 21.192 ± 0.2 | 11.8 ± 1.0 | 9.53 | 17.223 ± 0.43 | 10.4 ± 0.9 | 9.34 |
50 | 24.077 ± 0.63 | 28.471 ± 0.29 | |||||
25 | 38.488 ± 0.86 | 34.094 ± 0.58 | |||||
12.5 | 55.184 ± 1.0 | 51.845 ± 0.66 | |||||
6.25 | 82.073 ± 0.4 | 72.583 ± 0.55 | |||||
0 | 100 ± 0.0 | 100 ± 0.0 | |||||
HepG2 | 100 | 32.199 ± 0.69 | 8.8 ± 0.3 | 12.78 | 25.817 ± 0.78 | 12.0 ± 0.4 | 8.1 |
50 | 32.185 ± 0.4 | 32.358 ± 0.81 | |||||
25 | 40.619 ± 0.37 | 46.471 ± 0.83 | |||||
12.5 | 52.323 ± 0.29 | 55.938 ± 0.52 | |||||
6.25 | 78.313 ± 0.78 | 81.755 ± 0.72 | |||||
0 | 100 ± 0.0 | 100 ± 0.0 |