Table 4 Multivariable analysis of association between MACCE according to achieved hsCRP levels and SUA Quintile levels.
MACCE | Number of patients with events | Crude HR | Adjusted HR a.b | ||
---|---|---|---|---|---|
No./total No. (%) | 95%CI | p value | 95%CI | p value | |
Overall population | |||||
SUA quintiles |  |  |  |  | < 0.001 d |
 Q1c | 165/3283(5.0) | Reference | — | Reference | — |
 Q2 | 165/3215(5.1) | 1.02(0.82–1.27) | 0.858 | 1.12(0.90–1.39) | 0.312 |
 Q3 | 159/3215(4.9) | 0.98(0.79–1.22) | 0.878 | 1.10(0.88–1.37) | 0.428 |
 Q4 | 187/3220(5.8) | 1.16(0.94–1.43) | 0.170 | 1.29(1.04–1.60) | 0.023 |
 Q5 | 259/3231(8.0) | 1.63(1.34–1.98) | < 0.001 | 1.65(1.34–2.03) | < 0.001 |
hsCRP ≥ 2 mg/L | |||||
SUA quintiles |  |  |  |  | < 0.001d |
 Q1c | 100/1615(6.2) | Reference | — | Reference | — |
 Q2 | 96/1530(6.3) | 1.033(0.78–1.37) | 0.818 | 1.13(0.85–1.50) | 0.402 |
 Q3 | 93/1503(6.4) | 1.011(0.76–1.34) | 0.937 | 1.11(0.83–1.48) | 0.501 |
 Q4 | 125/1571(8.0) | 1.312(1.01–1.71) | 0.043 | 1.42(1.02–1.87) | 0.011 |
 Q5 | 192/1846(10.4) | 1.743(1.37–2.22) | < 0.001 | 1.74(1.35–2.25) | < 0.001 |
hsCRP < 2 mg/L | |||||
SUA quintiles | Â | Â | Â | Â | 0.278 d |
 Q1c | 65/1742(3.7) | Reference | — | Reference | — |
 Q2 | 69/1784(3.9) | 1.033(0.74–1.45) | 0.853 | 1.10(0.78–1.54) | 0.603 |
 Q3 | 66/1798(3.7) | 0.979(0.70–1.38) | 0.906 | 1.05(0.74–1.49) | 0.785 |
 Q4 | 62/1741(3.6) | 0.951(0.67–1.35) | 0.776 | 1.05(0.73–1.50) | 0.800 |
 Q5 | 67/1468(4.6) | 1.236(0.88–1.74) | 0.224 | 1.29(0.90–1.85) | 0.170 |