Table 4 Multivariable analysis of association between MACCE according to achieved hsCRP levels and SUA Quintile levels.

From: Effect of high sensitivity C-reactive protein on uric acid-related cardiometabolic risk in patients with coronary artery disease—a large multicenter prospective study

MACCE

Number of patients with events

Crude HR

Adjusted HR a.b

No./total No. (%)

95%CI

p value

95%CI

p value

Overall population

SUA quintiles

    

< 0.001 d

 Q1c

165/3283(5.0)

Reference

—

Reference

—

 Q2

165/3215(5.1)

1.02(0.82–1.27)

0.858

1.12(0.90–1.39)

0.312

 Q3

159/3215(4.9)

0.98(0.79–1.22)

0.878

1.10(0.88–1.37)

0.428

 Q4

187/3220(5.8)

1.16(0.94–1.43)

0.170

1.29(1.04–1.60)

0.023

 Q5

259/3231(8.0)

1.63(1.34–1.98)

< 0.001

1.65(1.34–2.03)

< 0.001

hsCRP ≥ 2 mg/L

SUA quintiles

    

< 0.001d

 Q1c

100/1615(6.2)

Reference

—

Reference

—

 Q2

96/1530(6.3)

1.033(0.78–1.37)

0.818

1.13(0.85–1.50)

0.402

 Q3

93/1503(6.4)

1.011(0.76–1.34)

0.937

1.11(0.83–1.48)

0.501

 Q4

125/1571(8.0)

1.312(1.01–1.71)

0.043

1.42(1.02–1.87)

0.011

 Q5

192/1846(10.4)

1.743(1.37–2.22)

< 0.001

1.74(1.35–2.25)

< 0.001

hsCRP < 2 mg/L

SUA quintiles

    

0.278 d

 Q1c

65/1742(3.7)

Reference

—

Reference

—

 Q2

69/1784(3.9)

1.033(0.74–1.45)

0.853

1.10(0.78–1.54)

0.603

 Q3

66/1798(3.7)

0.979(0.70–1.38)

0.906

1.05(0.74–1.49)

0.785

 Q4

62/1741(3.6)

0.951(0.67–1.35)

0.776

1.05(0.73–1.50)

0.800

 Q5

67/1468(4.6)

1.236(0.88–1.74)

0.224

1.29(0.90–1.85)

0.170

  1. a. Multivariable factors: sex, age, acute myocardial infarction, previous myocardial infarction, hypertension, heart failure with reduced ejection fraction, smoking, chronic kidney disease, percutaneous coronary intervention;.
  2. b. p = 0.037 for interaction between SUA quintile and hsCRP 2 mg/L or more vs. less than 2 mg/L for MACCE;.
  3. c. Each subsequent quintile is compared with the first quintile. Median (range) SUA values per SUA quintile: Q1, 3.79 (0.06–4.49); Q2, 4.91 (4.50–5.29); Q3, 5.66 (5.30–6.04); Q4, 6.48 (6.05–6.98); and Q5, 8.12 (6.99–17.43);.
  4. d. p for trend.