Figure 2

Functional enrichment analysis of DEPs with GO and KEGG. (A, C, E) GO analysis of DEPs (Plot A for DEPs in TN vs. NN, Plot C for DEPs in TD vs. ND, Plot E for DEPs in TD vs. TN). The gene ontology categories of DEPs are based on biological processes (BP), molecular functions (MF), and cellular components (CC). (B, D, F) KEGG pathway enrichment analysis of DEPs (Plot B for DEPs in TN vs. NN, Plot D for DEPs in TD vs. ND, Plot E for DEPs in TD vs. TN). The circle’s color represents the degree of enrichment corresponding to the results of KEGG enrichment, and the size of the circle depicts the number of DEPs in the pathway. DEPs, differentially expressed proteins; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes. TN vs. NN, tumor tissues versus adjacent normal colorectal tissues from non-diabetic patients; TD vs. ND, tumor tissues versus adjacent normal colorectal tissues from diabetic patients; TD vs. TN, tumor tissues from people with diabetes versus those from non-diabetics.