Fig. 5 | Scientific Reports

Fig. 5

From: CIGB-300 internalizes and impairs viability of NSCLC cells lacking actionable targets by inhibiting casein kinase-2 signaling

Fig. 5

CFM images showing JC1-Red/Green fluorescence ratio as marker for mitochondrial membrane depolarization induced by CIGB-300. (a) Representative images after 6 h incubation with CIGB-300 (IC50) in A549 cells; The quantification of four independent fields (> 10 ROI) is shown for A549 (b) and NCI-H226 (c) cells. CCCP, positive control. veh, Vehicle incubated cells. Images were acquired with an optical zoom of 20X and digital zoom of 1X. Selected groups were compared against veh using an Unpaired t-test (two-tailed) and statistical differences, when found, denoted as: *, p < 0.05; **,p < 0.01; ***, p < 0.001.

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