Fig. 1

(A) Chemical structure of the CADA compound. (B) Structural model of the Sec61 protein channel. (C) Superimposed binding poses of CADA on the Sec61 protein channel. Left: Yellow (AutoDock Vina) and Gray (cryo-EM, RCSB ID: 8DO2). Right: Yellow (AutoDock Vina without Meeko treatment) and Gray (cryo-EM, RCSB ID: 8DO2).