Table 6 Solubility classes of the designed, bioavailable, low toxicity CADA analogs.

From: Cutting-edge Bioinformatics strategies for synthesizing Cyclotriazadisulfonamide (CADA) analogs in next-Generation HIV therapies

 

LogS (ESOL)

Solubility Class

LogS(Ali)

Solubility Class

LogS (SILICOS-IT)

Solubility Class

CADA

-6.36

Poorly

-6.45

Poorly

-9.08

Poorly

JGL023

-5.03

Moderately

-5.90

Moderately

-6.66

Poorly

JGL024

-5.09

Moderately

-5.97

Moderately

-6.90

Poorly

JGL032

-5.98

Moderately

-7.30

Poorly

-7.41

Poorly

JGL047

-5.59

Moderately

-6.23

Poorly

-6.74

Poorly

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