Figure 1 | Scientific Reports

Figure 1

From: CXCL12/CXCR4 pathway as a novel therapeutic target for RNF213-associated pulmonary arterial hypertension

Figure 1

Development of pulmonary arterial hypertension in RNF213+/p.Arg4828Lys mice. (a) A single-strand oligodeoxynucleotide (ssODN) was designed in silico. (b) RNF213+/+ and RNF213+/p.Arg4828Lys mice were housed in normoxic and hypoxic environments. Body weight (c), right ventricular systolic pressure (RVSP) (d), and ratio of right ventricular weight to left ventricle plus septum weight [RV/(LV + S)] (e) were measured in each experimental group. (f) Representative elastica van Gieson staining of lungs from rats in each experimental group. Scale bars: 20 μm. (g) Percent medial wall thickness (%MWT) in small pulmonary arteries (20–60 μm in diameter) was measured (n = 16 arteries from four mice per group). Statistically significant p-values are shown. Hetero, heterozygous; Hx, hypoxia; Mut, mutant; Nx, normoxia; WT, wild-type.

Back to article page