Figure 5 | Scientific Reports

Figure 5

From: CXCL12/CXCR4 pathway as a novel therapeutic target for RNF213-associated pulmonary arterial hypertension

Figure 5

Histopathological images of lung specimens from patients. Representative images of lung specimens from two patients with the heterozygous RNF213 p.Arg4810Lys variant (panels a-h for patient #1, and panels i-t for patient #2) are demonstrated with the staining of alpha-smooth muscle actin (αSMA), vimentin, and CXC chemokine receptor type 4 (CXCR4) antibodies. Yellow triangles indicate vimentin-positive cells, red triangles indicate CXCR4 positive cells, and white triangles were cells in which vimentin and CXCR4 co-exist. Scale bars: 100 μm in panels a, b, c, d, i, j, k, and l; and 20 μm in panels e, f, g, h, m, n, o, p, q, r, s, and t. HE, hematoxylin and eosin stain.

Back to article page