Table 4 Cox proportional hazard regression analysis for progression-free survival after propensity score weighting.

From: 5-Fluorouracil combined with CalliSphere drug-eluting beads or conventional transarterial chemoembolization for unresectable hepatocellular carcinoma: a propensity score weighting analysis

Parameter

Univariate Analysis

Hazard Ratio (95% CI)

p-Value

Multivariate Analysis

Hazard Ratio (95% CI)

p-Value

TACE method

5-Fu-cTACE

5-Fu-DEB-TACE

1.00

0.57(0.33–0.97)

0.041

1.00

0.59(0.35–0.98)

0.044

Gender

 

0.793

  

Female

1.00

   

Male

0.92(0.52–1.62)

   

Age(years)

1.01(0.99–1.03)

0.227

  

Diabetes

No

Yes

1.00

1.39(0.75–2.58)

0.284

  

History of HB

No

Yes

1.00

1.07(0.64–1.81)

0.774

  

Liver Cirrhosis

No

Yes

1.00

0.91(0.58–2.02)

0.790

  

AFP(µg/L)

<400

≥ 400

1.00

0.97(0.52–1.80)

0.937

  

PIVKA-II(mAU/ml)

<40

≥ 40

1.00

1.61(0.85-3.05)

0.141

  

Ascites

No

Yes

1.00

2.59(1.51–4.46)

<0.001

1.00

2.00(1.01–3.96)

0.046

MELD

Low risk

Medium risk

1.00

4.65(3.01–7.19)

<0.001

1.00

2.47(1.23–4.93)

0.010

ALBI

Level 1

Level 2

1.00

1.39(0.80–2.41)

0.239

  

Child-pugh Stage

A

B

1.00

3.30(1.88–5.80)

<0.001

1.00

1.82(0.77–4.32)

0.17

ECOG performance status

0

1

2

1.00

1.38(0.71–2.67)

1.04(0.50–2.18)

0.339

0.905

  

BCLC Stage

A

B

C

1.00

2.63(1.19–5.84)

3.16(1.45–6.87)

0.016

0.003

1.00

2.30(1.05–5.02)

3.35(1.56–7.19)

0.036

0.001

Largest nodule size (cm)

≥ 5

<5

1.00

1.33(0.72–2.66)

0.325

  

Tumor multiplicity

Unifocal

Multifocal

1.00

1.25(0.74–2.12)

0.388

  

Vascular Invasion

No

Yes

1.00

1.78(1.04–3.07)

0.034

1.00

1.48(0.88–2.47)

0.13

Lymphatic Metastasis

No

Yes

1.00

1.42(0.84–2.41)

0.182

  

Extrahepatic metastasis

No

Yes

1.00

1.63(0.93–2.84)

0.082

  
  1. DEB-TACE, drug-eluting beads trans-arterial chemoembolization; cTACE, conventional trans-arterial chemoembolization; 5-Fu, 5-Fluorouracil; HB, hepatitis B; AFP, alpha-fetoprotein; PIVKA-II, Protein Induced by Vitamin K Absence or Antagonist-II; MELD, Model for End-Stage Liver Disease; ALBI, Albumin-Bilirubin; ECOG, Eastern Oncology Group; BCLC, Barcelona Clinic Liver cancer.