Fig. 2

Distribution characteristics of different PCD patterns in HCC. (A,B) Heatmap and volcano plot of the PCD-related DEGs between HCC and normal liver tissues. (C) The t-SNE analysis of two sample groups using 1109 DEGs. Such normal and HCC tissues formed their own clusters, and appeared distant from each other on t-SNE. (D,E) GO enrichment analysis of molecular functions (MF), biological processes (BP), and Kyoto Encyclopedia of Genes and Genomes (KEGG) terms. (F) Comparison of the relative levels of PCD patterns between two sample groups based on GSVA analysis. (G) Heatmap for the correlations between 16 PCD patterns and the 20 metabolism-related pathways by pearson’s analysis.