Fig. 9 | Scientific Reports

Fig. 9

From: Integrated multiomics analysis identified comprehensive crosstalk between diverse programmed cell death patterns and novel molecular subtypes in Hepatocellular Carcinoma

Fig. 9

scRNA-seq transcriptomic landscape of multicellular ecosystem in primary HCC and normal liver tissues. (A) Single cell transcriptome batch correction for different patient using the Harmony algorithm. (B) The distribution of specific cell populations across patients, samples, tissues, sites, viral infection status, and tumor stage. (C) The t-SNE plot of 37 cell clusters from the multicellular ecosystem of HCC patients. (D) Dot plot showing the canonical marker signatures of 8 major cell types in 37 cell clusters. (E) t-SNE plot of all cells with cell-type annotations. (F,G) t-SNE plot and stacked barplots showing the percentages of major cell types in each tumor site.

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