Fig. 9 | Scientific Reports

Fig. 9

From: In-Silico discovery of 17alpha-hydroxywithanolide-D as potential neuroprotective allosteric modulator of NMDA receptor targeting Alzheimer’s disease

Fig. 9

Visualization of NMDA relative orientation of GluN1b-GluN2B LBD heterodimers during the simulated timescale from molecular dynamic simulations trajectory analysis: The positioning of LBD heterodimers is defined by the distance between GluN1b Arg510 in loop1 (L10) and GluN2B Leu425 in loop2 (L2) in the D1 lobes, known as the L10-L2 distance at (a) first frame, (b) 50ns time scale frame and (c) last frame of the simulation.

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