Fig. 2 | Scientific Reports

Fig. 2

From: Sevoflurane exposure in early life: mitochondrial dysfunction and neurotoxicity in immature rat brains without long-term memory loss

Fig. 2

Altered metabolites associated with mitochondrial dysfunction in sevoflurane-induced neurotoxicity. (A) Top 30 metabolites with VIP score > 1 identified using OPLS-DA analysis. These metabolites were the most influential in separating the sevoflurane-treated group from controls. (B, C) Heatmap (B) and violin plot (C) showing significant metabolic variations between sevoflurane-treated and control groups. Metabolites with p < 0.05, VIP > 1, and fold change thresholds (> 1.5 or < 0.6) are highlighted. The heatmap represents relative abundances across the sample groups, while the violin plot illustrates the distributions of key metabolites between groups. D IPA network analysis integrating the key metabolites identified in parts A-C with transcriptomic data. The network highlights interactions between these metabolites, genes, and relevant pathways involved in mitochondrial function and neurotoxicity. Nodes represent metabolites or genes, while edges indicate known interactions. The color coding (orange for predicted activation, blue for predicted inhibition) indicates the predicted effects of sevoflurane exposure on these pathways.

Back to article page