Fig. 4
From: Preclinical pharmacology characterization of HX009, a novel PD1 x CD47 Bi-specific antibody

Individual blood drug concentration–time curve after single intravenous injection of HX009 in cynomolgus monkeys. (A) Intravenous (IV)-PK dose regimens. (B–D) The serum concentration–time curves of HX009 in individual animal following a single IV infusion at 1 mg/kg, or 3 mg/kg, or 10 mg/kg. (E) The serum concentration–time curves of HX009 in individual animal after the first dose in the repeated dose PK study. (F) The serum concentration–time curves of HX009 in individual animal after the last dose in the repeated dose PK study. Reference animal numbers are listed in the figures, e.g. 1M001 indicates the first male monkey in the first group, 1F001 indicates the first female monkey in the first group.