Fig. 5

The significant results of colocalization analysis. (A): In each plot, each dot represents a genetic variant. The casual SNP between cirrhosis and GM2A is rs72794132, while other SNPs are color-coded according to linkage disequilibrium (r2) in Europeans. SNPs lacking linkage disequilibrium information are coded as dark blue. On the left plot, the -log10 (P) values associated with cirrhosis risk are on the y-axis, and those related to protein levels are on the x-axis. On the right plot, genomic positions are on the x-axis, and the -log10 (P) values for GM2A are on the y-axis. The lower plot displays the -log10 (P) values and cirrhosis for the corresponding region. (B): In each plot, each dot represents a genetic variant. The casual SNP between cirrhosis and ADH1B is rs1229984, while other SNPs are color-coded according to linkage disequilibrium (r2) in Europeans. SNPs lacking linkage disequilibrium information are coded as dark blue. On the left plot, the -log10 (P) values associated with cirrhosis risk are on the y-axis, and those related to protein levels are on the x-axis. On the right plot, genomic positions are on the x-axis, and the -log10 (P) values for ADH1B are on the y-axis. The lower plot displays the -log10 (P) values and cirrhosis for the corresponding region.