Fig. 7 | Scientific Reports

Fig. 7

From: Oncolytic alphavirus-induced extracellular vesicles counteract the immunosuppressive effect of melanoma-derived extracellular vesicles

Fig. 7

Differentially Expressed Vesicular miRNAs in rSFV EVs. (A) Scatter plot illustrating vesicular miRNAs with elevated fold changes in EVs derived from rSFV cells. Labeled miRNAs highlight key regions based on fold change and mean expression levels (abundance). The color scale represents the density of miRNA probes overlapping the same position. (B) Dot plot depicting enriched pathways (adjusted p < 0.05) identified through hallmark (H), curated (C2), and ontology (C5) gene sets from the Molecular Signature Database (MSigDB). (C) Immune cell types with enriched expression of miRNA targets, based on data from the Immunologic Genome Project (ImmGen). *** indicates adjusted p < 0.001.

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