Fig. 9

The mechanical diagram of this study. HIF1α activates TPC2 expression, and increased STT3B-dependent TPC2 glycosylation promotes PASMC proliferation in response to hypoxia and exacerbates PAH via blocking autophagy.
The mechanical diagram of this study. HIF1α activates TPC2 expression, and increased STT3B-dependent TPC2 glycosylation promotes PASMC proliferation in response to hypoxia and exacerbates PAH via blocking autophagy.