Fig. 5 | Scientific Reports

Fig. 5

From: Yu-Ping-Feng-San improve the immunosuppression of microenvironment in hepatocellular carcinoma by promoting the maturation of DCs through the JAK2-STAT3 pathway

Fig. 5

STAT3 was a key target molecule for YPF to regulate the maturation of DCs. (A) DCs transfected with siRNA-STAT3 plasmid. (B) The maturation, (C) IL-12 secretion of mouse bone marrow-derived DCs induced by normal culture medium transfected with siRNA-STAT3 plasmids. (D) The maturation, (E) IL-12 secretion, (F) STAT3 protein expression of mouse bone marrow-derived DCs induced by tumor supernatant transfected with siRNA-STAT3 plasmids. Data are presented as the means ± SD. *P < 0.05 and **P < 0.01 vs. Vector group; #P < 0.05 and ##P < 0.01 vs. Control group; △P < 0.05 and △△P < 0.01 vs. Model group.

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