Table 5 Age- and sex- adjusted relative effect size estimates (exp(beta)) and corresponding 95% confidence intervals (95%-CI) for the interactions of rs4287174 alleles with education groups (years) on CRP values additionally including risk factor main effects and rs4287174 by risk factor interactions terms in separate linear regression models.

From: Socioeconomic position interacts with the genetic effect of a CRP gene common variant to influence C-reactive protein values

 

n

exp(ß)

(95% CI)

p

Body mass index (BMI)

4035

   

≤ 10y¥*rs4287174§

 

1.065

1.015; 1.117

0.012

11-13y¥*rs4287174§

 

1.047

1.009; 1.087

0.015

14-17y¥*rs4287174§

 

1.046

1.004; 1.091

0.034

BMI*rs4287174

 

1.000

0.998; 1.002

0.993

Total Cholesterol

4054

   

≤ 10y¥*rs4287174§

 

1.057

1.006; 1.108

0.028

11-13y¥*rs4287174§

 

1.044

1.005; 1.084

0.027

14-17y¥*rs4287174§

 

1.043

0.999; 1.089

0.056

Cholesterol*rs4287174

 

1.000

1.000; 1.000

0.911

Diabetes mellitus

4055

   

≤ 10y¥*rs4287174§

 

1.053

1.004; 1.106

0.035

11-13y¥*rs4287174§

 

1.042

1.003; 1.082

0.034

14-17y¥*rs4287174§

 

1.040

0.997; 1.085

0.071

Diabetes*rs4287174

 

1.001

0.967; 1.037

0.949

Coronary artery calcification (CAC)

3193

   

≤ 10y¥*rs4287174§

 

1.059

1.002; 1.119

0.041

11-13y¥*rs4287174§

 

1.031

0.990; 1.075

0.133

14-17y¥*rs4287174§

 

1.042

0.994; 1.091

0.085

CAC*rs4287174

 

1.000

1.000; 1.000

0.992

Dietary pattern index

3983

   

≤ 10y¥*rs4287174§

 

1.053

1.002; 1,106

0.042

11-13y¥*rs4287174§

 

1.045

1.006; 1.085

0.024

14-17y¥*rs4287174§

 

1.044

1.000; 1.090

0.052

Diet*rs4287174

 

0.999

0.995; 1.003

0.587

Current smoking

4055

   

≤ 10y¥*rs4287174§

 

1.055

1.005; 1.107

0.033

11-13y¥*rs4287174§

 

1.044

1.004; 1.084

0.029

14-17y¥*rs4287174§

 

1.042

0.998; 1.088

0.059

Active soking*rs4287174

 

1.006

0.980; 1.034

0.634

Hypertension

4055

   

≤ 10y¥*rs4287174§

 

1.055

1.006; 1.108

0.029

11-13y¥*rs4287174§

 

1.044

1.005; 1.084

0.027

14-17y¥*rs4287174§

 

1.043

0.999; 1.089

0.056

RR*rs4287174

 

0.983

0.948; 1.019

0.355

No exercise

4055

   

≤ 10y¥*rs4287174§

 

1.053

1.003; 1.106

0.037

11-13y¥*rs4287174§

 

1.042

1.003; 1.082

0.036

14-17y¥*rs4287174§

 

1.040

0.996; 1.085

0.072

Exercise *rs4287174

 

1.001

0.978; 1.024

0.952

  1. § included in the analysis using an additive genetic model with T as the effect allele and A as the reference allele; ¥highest education group ≥ 18y used as reference.
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