Table 4 COX regression analysis of all-cause mortality.

From: Evaluation of aortic arch calcification to predict prognosis after transcatheter aortic valve replacement

 

Univariate analysis

Multivariate analysis

 

p Value

HR (95%CI)

p Value

HR (95%CI)

Moderate/severe AAC

0.001

2.39(1.41–4.03)

0.037

1.78(1.04–3.06)

Age, per 5 years

< 0.001

1.53(1.23–1.91)

-

-

STS-PROM risk strata (versus low risk)a

< 0.001

-

0.011

-

Intermediate risk

0.021

3.59(1.21–10.69)

0.032

3.32(1.11–9.90)

High risk

< 0.001

7.51(2.67–21.15)

0.003

5.01(1.72–14.62)

Prior pacemaker

0.006

4.24(1.52–11.81)

-

-

CKD grade 4/5

< 0.001

3.47(1.92–6.27)

0.027

2.03(1.08–3.80)

Bicuspid aortic stenosis

0.005

0.45(0.26–0.78)

-

-

Low gradient AS

0.003

2.39(1.34–4.28)

0.018

2.04(1.13–3.68)

Moderate/severe MR

0.045

1.75(1.01–3.03)

-

-

  1. The variables with a p value < 0.05 in univariate analysis were showed. These variables were entered in multivariate cox regression analysis using a forward Likelihood Ratio method. No multicollinearity existed among the variables in multivariate regression model. a Patients were stratified by STS score: low risk (< 4%), intermediate risk (4–8%), and high risk (≥ 8%). Low gradient AS was defined as severe AS with mean gradient lower than 40 mmHg. AAC = aortic arch calcification; STS = Society of Thoracic Surgeon; STS-PROM = STS predicted risk of mortality; CKD = chronic kidney disease; AS = aortic stenosis; MR = mitral regurgitation.