Fig. 6 | Scientific Reports

Fig. 6

From: Short-term diet intervention comprising of olive oil, vitamin D, and omega-3 fatty acids alters the small non-coding RNA (sncRNA) landscape of human sperm

Fig. 6

Effect of the dietary intervention on miRNA expression. (a) Volcano plot showing differentially expressed miRNAs (intervention vs control) identified after adjusting for age, BMI, sperm concentration and motility. Horizontal dashed line represents the -log10 nominal p-value = 2 significance thresholds of association, and the vertical dashed lines represent the log2(1.5) fold change (b) Differentially expressed miRNAs and their corresponding target genes predicted by DIANA miRPath. Purple color (1) indicates the presence of the miRNA-target interaction, while grey color indicates the absence of a predicted interaction. (c) Ingenuity Pathway Analysis (IPA) of genes targeted by differentially expressed miRNA. Pathways with the most overrepresented genes and an enrichment -log10 FDR-corrected p-value > 2 are plotted by the decreasing order of significance. The dotted red line represents the ratio of the miRNA target genes to the total number of genes known to be present in that pathway.

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