Fig. 3 | Scientific Reports

Fig. 3

From: The regulatory role of ACP5 in the diesel exhaust particle-induced AHR inflammatory signaling pathway in a human bronchial epithelial cell line

Fig. 3

DEP-treated BEAS-2B cells express ROS and pro-inflammatory responses. (A) Top-10 activated pathways predicted by GO in DEP-treated ACP5 KO BEAS-2B cells compared with non-treated ACP5 KO BEAS-2B cells. (B) Heat map of hierarchical clustering of DEG related to inflammation for ACP5 KO BEAS-2B cells with or without DEP treatment (p < 0.05). (C) Differentially expressed genes in DEP-treated ACP5 KO BEAS-2B cells and non-treated ACP5 KO BEAS-2B cells were investigated by IPA to assess the correlation network of various inflammation-related pathways and transcription factors. (D) Expression levels of ROS-related genes were determined by qRT-PCR and normalized to GAPDH expression. (E) Expression levels of inflammation-related genes were determined by qRT-PCR. *p < 0.05, **p < 0.01, ***p < 0.001.

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