Fig. 6

Quantitative proteomics of the VL and soleus muscle of male and female Sprague–Dawley rats that have been exposed to the HFS diet for 12 weeks. (A) Proteomics workflow and analysis (N = 3, HFS males and N = 3, HFS females). Metascape software was used to identify pathway enrichment. A list of all detected proteins is provided in supplementary tables S1 and S2. (B) Metascape analysis of different pathways between HFS diet animals and Chow-fed control animals for the VL muscle. (C) Metascape analysis of different pathways between HFS diet and Chow-fed control animals for the soleus muscle. Blue writing indicates upregulated pathways.