Fig. 1

ZC3H12D expression levels in lung tumor tissues and paired normal tissues. A), Bodymap illustrating ZC3H12D expression enrichment. Red denotes cancer patients, green denotes normal subjects, and the shading indicates expression levels; B), Differences in ZC3H12D expression between lung tumor and normal tissues. mRNA level differences were derived from LUAD RNAseq data in the TCGA database; C), protein level differences were assessed through quantitative immunohistochemistry (IHC) analysis of 51 matched lung adenocarcinoma tumor and adjacent normal tissues; D), Representative pathological staining and IHC results are presented; E), Proteomics differences of ZC3H12D between lung tumor and normal tissues, derived from CPTAC database; F), t‑SNE plot of LUAD single cell transcriptomic data, illustrating distinct cellular clusters and the differential expression of ZC3H12D across various cell types. **** indicates p < 0.00005.