Fig. 8
Box plots illustrate the simulated AUC0–∞ with the 5th − 95th percentiles following a 30 mg oral dose of nicardipine in both healthy individuals and those with chronic kidney disease (CKD) (a). Suggested dosage reductions for patients with moderate and severe renal impairment are presented in (b) for comparison with the exposure levels in healthy individuals. AUC0–∞: area underneath the curve from time zero to infinity.
