Table 5 Calculation of the AFE values for PK variables among healthy and diseased populations.

From: A PBPK modeling approach for personalized dose optimization of nicardipine in renal and hepatic dysfunction

PK variables

AFE

IV healthy

 Cmax (ng/mL)

0.896

 AUC0–∞ (ng.h/mL)

0.951

 CL (L/h)

1.059

Oral healthy

 Cmax (ng/mL)

1.167

 AUC0–∞ (ng.h/mL)

1.089

 CL/F (L/h)

0.945

Renal failure

 Cmax (ng/mL)

0.702

 AUC0–∞ (ng.h/mL)

0.776

 CL/F (L/h)

1.322

Liver cirrhosis

 Cmax (ng/mL)

1.109

 AUC0–∞ (ng.h/mL)

0.563

 CL/F (L/h)

1.775

  1. PK pharmacokinetics, AUC0–∞ area underneath the curve from time zero to infinity, Cmax maximal plasma concentration, CL clearance, AFE average fold error.
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