Fig. 5
Correlations with clinical demographics and laboratory biochemistry. Correlation plots illustrate spearman correlations between clinical indices and specific plasma metabolites and lipids in Module I and Module II of the MEGENA global network. Only correlations with P < 0.05 were indicated with colored circles. Positive correlations were shown in red and negative correlations were shown in blue, with sizes of circles representing the strength of the significance p-value and intensity of color representing the magnitude of the correlation coefficients. (A) Correlation analyses between plasma indoles and PE-Os with clinical and biochemical measures amongst Omicron-infected patients (n = 66). (B) Correlation analyses between plasma L-histidine and top 30 differential TAGs with clinical and biochemical measures amongst first infection Omicron patients (n = 28). Differential TAGs were selected based on ascending P values from Student’s t-test between first infection patients (n = 28) and healthy controls (n = 20). PE O, plasmalogen phosphatidylethanolamine; CRP, C-reactive protein; ALT, alanine transaminase; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; eGFR, estimated glomerular filtration rate; sCD40L, soluble cluster of differentiation 40 ligand; EGF, epidermal growth factor; FGF-2, fibroblast growth factor 2; FLT-3 L, FMS-like tyrosine kinase 3 ligand; G-CSF, granulocyte colony stimulating factor; GM-CSF, granulocyte-macrophage colony stimulating factor; GRO-alpha, growth regulated protein alpha; IFN, interferon; IL, interleukin; MCP, monocyte chemoattractant protein; MDC, macrophage-derived chemokine; MIG, monokine induced by interferon-gamma; MIP, macrophage inflammatory protein; PDGF, platelet-derived growth factor; RANTES, regulated upon activation, normal T cell expressed and presumable secreted; TGF, transforming growth factor; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor; TAG, triacylglycerol; CRP, C-reactive protein. ALT, alanine transaminase.
