Fig. 6
From: SBK3 suppresses angiotensin II-induced cardiac hypertrophy by regulating mitochondrial metabolism
Overexpression of SBK3 suppressed Drp1 phosphorylation at S616 in ARCMs. (A,B) Representative images (A) and quantitative analysis of OPA1 (n = 3), Mfn1 (n = 5), Mfn2(n = 4) protein expression detected by western blot in rat cardiomyocytes after 5 μM of Ang II for 24 h (B). (C,D) Representative images (C) and quantitative analysis of Drp1 (n = 3), p-Drp1 (n = 4) protein expression detected by western blot in rat cardiomyocytes after 5 μM of Ang II for 24 h (D). Overexpression of SBK3 reduced the level of p-Drp1 in rat cardiomyocytes. The data were expressed as Mean ± SEM. *P < 0.05, **P < 0.01, ns, non significant; one–way ANOVA test, followed by the Newman–Keuls test.
