Table 1 Baseline characteristics of the three cohorts, focusing on patients and in-hospitalized time points after preprocessing. For categorical features, their occurrences are described, while for numerical features, their mean and standard deviation are specified.

From: Profiling short-term longitudinal severity progression and associated genes in COVID-19 patients using EHR and single-cell analysis

 

KNUH

KNIH

NCCAP

Train

Internal validation

External validation

COVID-19

Pneumonia

Feb.2020 - Oct.2022

Jan.2021 - Sep.2022

Mar.2020 - Feb.2023

Demographics

(Baseline: # of patients)

Number of patients (n)

4,509

443

33

Age

62.45 ± 18.81

52.64±16.55

71.31±11.96

Gender (male, n, %)

2,232 (49.50)

244 (55.08)

23 (71.88)

Weight (kg)

63.45 ± 21.57

67.60±14.46

-

Height (cm)

163.53 ± 26.35

165.09±9.53

-

Mortality (n,%)

375 (8.32)

5 (1.13)

8 (25)

Clinical features

(Baseline: # of admission timepoints)

Vital signal

Temperature (\(^{\circ }{C}\))

36.54 ± 0.33

37.23 ± 0.73

36.57 ± 0.32

Systolic Blood Pressure (mmHg)

124.21 ± 15.22

114.46 ± 15.42

122.60 ± 17.15

Diastolic Blood Pressure (mmHg)

73.38 ± 9.75

72.62 ± 11.50

72.29 ± 10.99

Pulse (BPM)

81.16 ± 14.46

83.06 ± 14.72

91.59 ± 13.39

Breath (BPM)

20.27 ± 2.69

20.11 ± 3.67

19.36 ± 3.74

Saturation of Partial pressure Oxygen (%)

97.77 ± 1.76

96.55 ± 12.33

98.19 ± 1.50

Laboratory test

Blood Urea Nitrogen (mg/dL)

28.59 ± 23.48

17.03 ± 12.12

33.15 ± 26.35

Creatinine (mg/dL)

1.46 ± 1.98

0.97 ± 1.27

1.72 ± 1.87

Hemoglobin (g/dL)

11.49 ± 2.26

12.83 ± 1.96

9.69 ± 1.84

Lactate Dehydrogenase (U/L)

341.97 ± 307.75

474.14 ± 367.25

455.36 ± 551.78

Lymphocytes (%)

18.17 ± 13.20

23.27 ± 12.98

12.42 ± 9.27

Neutrophils (%)

71.76 ± 16.64

66.79 ± 15.60

78.34 ± 13.40

Platelet count (\(10^3\)/uL)

214.93 ± 116.01

227.53 ± 96.53

243.98 ± 158.32

White Blood Cell count (\(10^3\)/uL)

8.83 ± 6.72

6.98 ± 4.66

10.92 ± 13.78

C-Reactive Protein (mg/dL)

4.25 ± 5.82

2.57 ± 3.96

7.40 ± 6.87

O2 treatments (n, %)

(Baseline: # of admission timepoints)

Room air

29,252 (62.85%)

3,576 (76.85%)

165 (23.44%)

Nasal

8,074 (17.35%)

528 (11.35%)

286 (40.62%)

Mask

769 (1.65%)

45 (0.97%)

23 (3.27%)

High Flow Nasal Cannula

4,918 (10.57%)

249 (5.35%)

117 (16.62%)

Ventilation tube

3,529 (7.58%)

255 (5.48%)

113 (16.05%)