Fig. 1

HYPERLINK "sps:id::fig1||locator::gr1||MediaObject::0" CD40-TRAF6 inhibition ameliorated acute rejection and prolonged the survival of cardiac allografts in the murine cardiac transplantation acute rejection model. (A) The murine cardiac heart transplantation model was performed using BALB/C mice as donors and C57BL/6 mice as recipients. CD40-TRAF6 specific antagonist 6,877,002 (CT6i for short) or DMSO was administered after transplantation. (B) Survival of cardiac allografts in each group.(p = 0.002). (C) HE staining of cardiac allografts 7 days after heart transplantation. DMSO vs CT6i. (D) Masson staining of cardiac allografts 7 days after heart transplantation. (E) Immunohistochemical assay of cardiac allografts infiltrated by CD4 + and CD11b + cells. (F) Parenchymal rejection scores of cardiac allografts were evaluated on day 7 after cardiac transplantation. The CT6i group exhibited lower PR scores than the DMSO group (n = 5 for each group)(p = 0.001).