Fig. 2 | Scientific Reports

Fig. 2

From: Repeated 5-aminolevulinic acid mediated sonodynamic therapy using magnetic resonance guided focused ultrasound in rat brain tumour models

Fig. 2

(A) For the 9L brain tumour treatment, the treatments started seven days after the tumour implantation, and the following treatments were conducted at 14 and 21 days. (B) The representative T1 contrast-enhanced (T1-CE) MR images of control, FUS alone, 5-ALA alone, and SDT treatment. At day 28, the 9L tumour is significantly shrunk. The surviving animals were followed up for 80 days. (C) The representative H&E stains of all groups. On day 80, the animals that underwent SDT were tumour-free. The rest showed an enormous brain tumour volume. (D) The tumour growth curve was analyzed using the One-way ANOVA with post-Dunn’s test. The significance can be found in the comparison between SDT and the other three groups. (E) Survival was analyzed using the log-rank test, and a p-value of 0.003 was shown. After three treatments, SDT showed a significant tumour reduction, and all the animals survived to the designated endpoint. (F) No difference in animal body weight was found among all groups during the three weeks of treatments, indicating the animals tolerated SDT well.

Back to article page