Fig. 3 | Scientific Reports

Fig. 3

From: Repeated 5-aminolevulinic acid mediated sonodynamic therapy using magnetic resonance guided focused ultrasound in rat brain tumour models

Fig. 3

(A) To investigate late-stage tumours in response to SDT, the weekly therapy started from Day 16 and continued for the following two weeks. The FUS targets varied in correlation to the tumour sizes. (B) A solid tumour was shown in the right striatum on Day 16. After two treatments, a clear necrotic centre appeared in the T2w images on Day 30, indicating the efficiency of SDT. (C) The tumour volume comparison between Day 7 and Day 16 brain tumours indicates the significance of the late-stage tumour volume. (D) Kaplan-Meier survival analysis where groups were compared with a log-rank test and a Bonferroni correction for multiple comparisons; p = 0.002.

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