Fig. 4 | Scientific Reports

Fig. 4

From: Repeated 5-aminolevulinic acid mediated sonodynamic therapy using magnetic resonance guided focused ultrasound in rat brain tumour models

Fig. 4

(A) We further investigate the efficiency of SDT in the human glioblastoma U87 rat model. The animal received three weekly treatments beginning from day 7. (B) The representative T1 contrast-enhanced MR images of control, FUS alone, 5-ALA alone, and SDT treatment. The first row in the SDT group demonstrated the long-term tumour-free survivor. The tumour disappeared after three treatments. However, SDT had a minimal impact on some animals, such as the second row in the SDT group. (C) The H&E stains stood for the animals from (B), respectively. (D) A significant difference was found in the third week between the control group and the SDT group. (E) The log-rank test showed prolonged survival in the SDT group, p = 0.01. (F) The body weight in all groups did not vary during three-week treatments.

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