Fig. 2 | Scientific Reports

Fig. 2

From: Identification of a novel disulfidptosis-related gene signature in osteoarthritis using bioinformatics analysis and experimental validation

Fig. 2

Identification of disulfidptosis-related differentially expressed genes (DR-DEGs) in OA patients. (A) Principal component analysis (PCA) plots before and after batch correction in the training set. (B) PCA plots before and after batch correction in the validation set. (C) Heatmap of the 10 DR-DEGs. Green represents low expression genes in the samples, and orange represents high expression genes in the samples. (D) Differential expression analysis of the 17 DRGs. Green represents control samples, and orange represents OA samples. (E) Circos plot illustrating the chromosomal ___location distribution of the top 9 DR-DEGs. (F) Correlation analysis of the top 9 DR-DEGs. Blue indicates negative correlation, and red indicates positive correlation. (G) GO functional analysis of the 10 DR-DEGs, including BP, MF, and CC. (H) KEGG pathway analysis of the 10 DR-DEGs. (I) Gene-miRNAs interaction analysis of the 10 DR-DEGs. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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