Fig. 7 | Scientific Reports

Fig. 7

From: Enhancing epigenetic aging clocks in cetaceans: accurate age estimations in small endangered delphinids, killer whales, pilot whales, belugas, humpbacks, and bowhead whales

Fig. 7

Genomic-region based transcription factor binding site enrichment analysis. The heatmap displays transcription factor (TF) binding site enrichment for age-associated CpGs, evaluated against a background surrounding 37 k mammalian CpGs with a 200 bp buffer. The left and right panels present the enrichment analysis for the top 1000 CpGs that increased or decreased with age, respectively. The columns along the x-axis represent results from EWAS across all tissues, blood, and skin types. Rows are organized by TF genes grouped into different families, with color bands in the rightmost column indicating these families. Each cell shows an odds ratio (unadj. hypergeometric p-value) where p < 0.05.

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