Fig. 8

Effects of PLK3 knockdown on LCs under OS. (A) Knockdown efficiency of PLK3 in LCs. (B) Increased cell proliferation ability in si-PLK3 treated LCs under 200 µM H2O2 stress after 24 h. (C) Reduced ROS levels in si-PLK3 LCs compared to si-NC after H2O2 treatment. Scale bar = 200 μm. (D) Enhanced T-AOC, GSH-Px and SOD activity in si-PLK3 LCs with no change in MDA content post-H2O2 treatment. The values are expressed as mean ± SEM (n = 3 biological repetitions). *, ** and *** represent P < 0.05, P < 0.01, and P < 0.001 respectively.