Fig. 5
Noradrenaline-induced contractions in laser-enucleated tissues, grouped for preoperative catheterization and preoperative treatment with α1-blockers. Data from noradrenaline-induced contractions were grouped as indicated, for preoperative catheterization of patients due to urinary retention (a), for preoperative treatment with α1-blockers (b), or both (c-f). Patients’ data regarding catheterization were available from 57 patients (31 without, 26 with catheter), and regarding medical treatment from 59 patients (34 treated, 25 not treated with α1-blockers), from a total of 61 patients participating in this series. Shown are means ± standard deviation (SD) in concentration response curves, and all single values for Emax and EC50 calculated by curve fitting (each value representing one prostate tissue, examined by single or multiple determinations) together with means (bars). Concentration response curves were compared by two-way ANOVA. Emax and EC50 values were compared by unpaired, two-tailed t test if data were normally distributed in both groups (i. e., EC50 values in (a) and (e)), and by unpaired, two-tailed Mann Whitney test if data were not normally distributed in at least one of both groups (all others). P values ≥ 0.05 are not shown. One EC50 value (labelled by grey color) could not be calculated by curve fitting, as the sample showed no contraction (corresponding to an Emax of 0% of KCl), but was set to the highest noradrenaline concentration applied in these series, i.e. -4 for illustration.
