Fig. 5 | Scientific Reports

Fig. 5

From: Investigation of the mechanism of chenodeoxycholic acid in treating acute lung injury through network pharmacology and experimental validation

Fig. 5

KEGG pathway enrichment map of potential targets of CDCA in the treatment of ALI. The identified pathways include Bile secretion, Prostate cancer, Chemical carcinogenesis–receptor activation, Central carbon metabolism in cancer, Th17 cell differentiation, Alcoholic liver disease, Nitrogen metabolism, HIF-1 signaling pathway, Gastric acid secretion, Proximal tubule bicarbonate reclamation, PD-L1 expression and PD-1 checkpoint pathway in cancer, NOD-like receptor signaling pathway, Legionellosis, Calcium signaling pathway, Kaposi sarcoma-associated herpesvirus infection, Antifolate resistance, Steroid hormone biosynthesis, Pancreatic secretion, Propanoate metabolism, and Inflammatory bowel disease. Pathway significance is represented by -log10 (p-value), with a greater intensity of red indicating higher significance. The horizontal axis reflects the target count in each pathway.

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