Fig. 1
From: Activin A affects colorectal cancer progression and immunomodulation in a stage dependent manner
Signaling patterns in the TME are both activin- and stage-dependent. DSP technology was employed to separate regions of interest (ROIs) into stroma or tumor containing samples. (A-B) Representative ROIs labeled as tumor or stroma, (C-D) these images were further separated into activin positive (pink) and activin negative (gray) areas of illumination (AOIs) prior to collection and quantification. (E) Representative heatmap of the expression of each quantified protein within each sample when separated across stage, tissue compartment, and activin co-localization which identified the strongest heat sig-natures in the stage III tissue samples where activin was found.
