Fig. 3

Comparative structural analyses of mAbs bound to similar RSV G CCD conformations reveal distinct interactions. (A) Overlay of RSV G CCD structures when bound to antibodies 1G1 (pink, PDB code 9CQA), 3D3 (pale green, PDB code 5WNA), 1G8 (periwinkle, PDB code 9CQB), 3G12 (yellow, PDB code 6UVO), 2B11 (blue, PDB code 9CQD), 2D10 (orange, PDB code 5WN9), CB002.5 (salmon pink, PDB code 6BLI), and CB017.5 (turquoise PDB code 6BLH). (B) Overlay of the structures Fab 1G1 (pink surface and ribbon model) and Fab 3D3 (green surface and ribbon model) bound to RSV G CCD (ribbon model in magenta when bound to Fab 1G1 and forest green when bound to Fab 3D3). (C, D) Overview and zoom-in of the overlay of the structures of Fab 1G8 (purple) and Fab 3G12 (goldenrod) bound to RSV G CCD (ribbon model in sea green when bound to Fab 1G8 and gold when bound to Fab 3G12). In panel C, sea green dotted lines represent hydrogen bonds between Fab 1G8 and RSV G CCD, and gold dotted lines represent hydrogen bonds between Fab 3G12 and RSV G CCD. All 3D protein structures in this figure were rendered in ChimeraX version 1.6.1 (https://www.rbvi.ucsf.edu/chimerax)⁶⁸.