Fig. 2 | Scientific Reports

Fig. 2

From: Zwitterionic poly-carboxybetaine-dexamethasone conjugates do not alleviate cartilage degeneration and synovitis in the collagenase-induced osteoarthritis model in rats

Fig. 2

DEX and pCBAA-DEX do not prevent cartilage degeneration: (A) Representative computed tomography surface roughness maps for the four study groups. Scale bar: 1 mm. (B) Calculation of the CRS reveals no reduction in surface roughness upon treatment with either DEX or pCBAA-DEX. The latter even causes an increase in CRS in the tibia. (C) Representative Safranin O staining of the tibial plateaus of our four study groups. Scale bars: 500 μm (top), 100 μm (bottom). (D) Grading of the cartilage with the OARSI cartilage degeneration score38 matched the CRS results, as did the assessment of the total cartilage degeneration width (E) and the significant cartilage degeneration width (F). M: medial, L: lateral, N = 8. See Figures S2/3 and S12-19 for the full CRS and histology dataset. Note that all data comparisons without asterisks were statistically non-significant.

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