Fig. 3 | Scientific Reports

Fig. 3

From: Identification of potential shared gene signatures between periodontitis and breast cancer by integrating bulk RNA-seq and scRNA-seq data

Fig. 3

Identification of the hub genes using machine learning methods. (a) Venn diagram showing the 21 genes selected from the union set between the DEGs and trait-module key genes in WGCNA. (b) GO analysis of the shared genes. (c) KEGG pathway enrichment analysis of the shared genes. (d-e) LASSO and RF algorithms were conducted to determine the hub genes in PD. (f-g) LASSO and RF algorithm were conducted to determine the hub genes in BC. (h) Venn diagram showing the shared hub genes for PD and BC. PD: periodontitis; BC: breast cancer; DEG: differentially expressed gene; WGCNA: weighted gene co-expression network analysis; LASSO: least absolute shrinkage and selection operator; RF: random forest.

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