Fig. 1 | Scientific Reports

Fig. 1

From: CaMK2A/CREB pathway activation is associated with enhanced mitophagy and neuronal apoptosis in diabetic retinopathy

Fig. 1

Morphological and histological changes in the diabetic retinopathy (DR) model. (A) H&E staining showing degeneration of retinal cells in the DR model group. (B) Quantification of retinal thickness indicating retinopathy in the model group. (C) Apoptosis analysis demonstrating increased cell death in retinal tissues of the model group. (D) ELISA quantification revealing reduced neurotransmitter production (Dopamine and DOPAC) in DR tissues. (E) Transmission electron microscopy (TEM) analysis showing engulfment of mitochondria by autophagosome membranes in DR tissues. (F) Protein expression levels of mitophagy markers (LCBII, Parkin, PINK1) and Drp1 in DR tissues. (G) Protein levels of CaMK2A and phosphorylated CREB in DR tissues. N=6 animals in each group. *p<0.05; **p<0.01; ***p<0.001; ****p<0.0001.

Back to article page